Sangue artificiale, un traguardo sempre più vicino.

By 19 maggio 2017 Healtcare

Sangue artificiale, grazie a due ricerche della Cornell University di New York e dell’Harvard Medical School di Boston, sono state create in laboratorio cellule staminali ematopoietiche (CSE), ovvero le staminali da cui hanno origine tutte le cellule del sangue. Un passo avanti decisivo che getta le basi per creare riserve illimitate di cellule sane e personalizzate, fondamentali sia per le trasfusioni che per la lotta contro i tumori, soprattutto le leucemie e le anemie.

Decifrare le staminali e i processi di auto-rinnovamento

“Questo è un passo avanti fondamentale che ci porta più vicini non solo a una cura per le malattie del sangue, ma anche a decifrare la complessa biologia delle cellule staminali e i loro processi di auto-rinnovamento”, ha sottolineato il professor Shahin Rafii, direttore dell’Ansary Stem Cell Institute e autore principale dello studio condotto dall’ateneo di New York. Le cellule staminali emopoietiche hanno come peculiarità proprio quella di “auto-rinnovarsi”, diventando miliardi nell’arco dell’intera vita.

A risultati analoghi è giunto il team di ricerca del dottor Shahin Rafii, che ha ricavato le CSE dalle cellule endoteliali vascolari, che rivestono i vasi sanguigni, mediante un esperimento sui topi.

I ricercatori della Harvard Medical School, in collaborazione con i colleghi del Dana Farber Cancer Institute, sono invece partiti dalle cellule staminali umane pluripotenti, quelle cellule in grado di generare tutti i tipi di altre cellule del nostro organismo. Una volta riprogrammate per trasformarsi nelle cellule endoteliali dei vasi sanguigni, le hanno trattate con una “salsa speciale di proteine”. Poi le cellule sono state trapiantate nel midollo osseo dei topi, dove in due esemplari su cinque hanno dato origine a varie tipologie di cellule del sangue. I dettagli delle ricerche condotte a New York e a Boston sono stati pubblicati sulla rivista Nature. Recentemente i ricercatori dell’Università di Bristol, che hanno pubblicato il loro studio su Nature Communications, hanno trovato il modo di produrre sangue artificiale in grandi quantità da cellule staminali “immortali”. Secondo quanto spiegano gli autori, il sangue sintetico poteva già essere prodotto a partire da staminali, che però nel processo muoiono, rendendo impossibile produrne quantità elevate. Già un team di ricercatori della Washington University School of Medicine di St Louis aveva infatti creato del sangue artificiale in polvere, in grado di espletare tutte le funzioni naturali di quello umano con la semplice aggiunta di acqua. L’innovazione apportata dagli scienziati di Bristol consiste nello sviluppo di un processo che, a partire da staminali adulte, ottiene cellule eritroidi, che fanno da precursore ai globuli rossi, in grado di replicarsi. Ecco perché sono state definite “immortali”. In precedenza una ricerca svedese aveva scoperto che è possibile produrre sangue artificiale utilizzando una particolare proteina contenuta nella barbabietola da zucchero, molto simile all’emoglobina umana.

Sangue artificiale, test su pazienti con gruppi rari

E’ grazie a questo procedimento che in laboratorio sono stati ottenuti “litri” di globuli rossi, mentre i test di sicurezza su eventuali trasfusioni con questo ‘sangue artificiale’ partiranno entro l’anno, con l’obiettivo di usarli per le persone che hanno caratteristiche del sangue come la presenza o l’assenza di proteine che rendono impossibili le trasfusioni.

“Il primo uso terapeutico di globuli rossi prodotti in questo modo – spiega David Anstee – sarà probabilmente per pazienti con gruppi sanguigni rari, per cui la donazione tradizionale può essere una fonte difficile”.

 Fonte: datamanager.it

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  • Also den ersten Stomp Film hab ich auf VHS, aber bei dem hier fand ich ja schon alleine den Trailer doof

  • Qu’un excité se mette à jouer les cow-boys, c’est tragique, mais ici il semble bien que l’affaire mette en jeu la justice qui a libéré le criminel, la police qui a travesti, des médecins qui ont fait un rapport bidon. C’est tout un système qui apparaît au grand jour, et c’est beaucoup plus grave.

  • IN4AIR is de benaming van de outdoor collectie van Bert Plantagie . Dit Nederlandse meubelmerk heeft prachtige, kunststof vlechtwerk tuinstoelen en loungesets direct uit voorraad leverbaar. Je kunt kiezen uit drie kleuren voor het vlechtwerk en wel acht kleuren voor de kussens. Omdat het merk gaat stoppen met haar outdoor collectie zit er bovendien een korting van 65% op al het vlechtwerk.

  • I went over this site and I think you have a lot of good information, saved to fav 🙂

  • not much to add to this one. nicely done. the charlie rose interview is an especially good rebuke to the typical propaganda since rose sounded like a stuck record at points and didn’t leave much room for doubt (and i mean that in a good way for once since that interview was one of his “stopped clock” moments and he did a pretty decent job.) the interview also references the hamas charter, but charters and resolutions have as much relevance in the region as the complaint box does at BP headquarters.

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  • Great guitar sound on the intro of “The Living”. I kinda wish they would have kept it there, rather than receding it in the mix for a more synth drive over top.Still – a rather catchy tune.Best line – “you had the best night – it’s all on your website”

  • I feel your pain — every time I find myself in a dressing room with the two little boys with me I ask myself when am I ever going to learn that it is simply impossible to buy clothes for myself with my munchkins underfoot. And bedtimes around here are a joke! And I also need to work on the yelling / patience thing. We all do. This parenting thing is a tough job, and even harder when it’s just you. Hang in there, you are a wonderful mom!

  • I'm in LOVE with this. Maybe I don't like eggnog all too much because the idea of drinking raw eggs is about as appealing as sticking a fork in my eye. But this nog looks fantastical, Mandy!

  • Overall RatingValue Not Rated Screen QualityBattery LifeStylePicture QualityEase of UseNikon D5100 is a fantastic camera for photo and video. The only problem I have with it is that autofocus in Live is a little slow. A bit pricey, but excellent.

  • To an actual WASP, being a WASP is not a big deal. To social strivers desperately trying to convince people they are not midwestern hicks but are, in fact, SOMEBODY, it’s a very big deal.

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